NFL Week 16 Upset Pick 2013: Which Football Game Has The Best Chance Of Beating The Spread?

There are several double-digit point spreads in Week 16, with Denver favored by 10.5 points over Houston, Seattle favored by the same amount over Arizona, San Diego holding a 10-point advantage over Oakland, and San Francisco is expected to blowout Atlanta by a minimum of 12.5 points. In today's NFL it's possible for any of those underdogs to emerge victorious, especially Arizona, but the best upset pick of the week belongs to the New York Giants over the Detroit Lions.